Yes, true Christians must stand against their own government (local, state, federal), if their own government stands against the Holy Bible, which is the Word of God.
“Christians” who are loyal to their earthly government, when it stands against the Holy Bible (Word of God) are not true Christians. True Christians are followers of Jesus Christ and champion the Word of Jesus Christ and Bible morality in society.
Chrisitans must not submit to earthly powers that stand against the Holy Bible.
That is important for all police officers, all FBI agents, all CIA agents, all Homeland Security officers, all NSA operatives, all US Marines, all US Military personnel, all US Secret Service personnel, all US Marshalls, all US civil servants in the US State Department, all secretaries and staff of US politicians on local, state, and federal levels.
True Christians must overtly stand against the earthly government and its politicians, judges, legislators, and representatives that intentionally downgrade the morality of the Holy Bible or the integrity of Biblical Christianity.
True Christians are not those who go to church. True Christians do go to church, but true Christians are those who will stand with Jesus Christ even if it means that the true Christian will lose everything he or she has.
The true disciple must deny himself, take up the cross and follow Jesus Christ.
In the context of the United States of America (or the United Kingdom or Canada or Germany or France, etc.), this means that true Christians must stand against their own earthly governments, when their earthly governments go against the Holy Bible.